Frontiers | Phosphodiesterase-4D Knockdown in the Prefrontal

pede4dThe PDE4 family contains four genes (PDE4A to PDE4D), only PDE4A, PDE4B, and PDE4D are expressed in the heart, each of which regulates different cAMP-dependentThe goal of this study was to determine whether a phosphodiesterase-4D (PDE4D) allosteric inhibitor (BPN14770) would improve cognitive function and behavioral outcomes in patients